KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM4
All Species:
38.79
Human Site:
Y249
Identified Species:
60.95
UniProt:
P33991
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33991
NP_005905.2
863
96558
Y249
N
E
I
F
F
D
R
Y
P
D
S
I
L
E
H
Chimpanzee
Pan troglodytes
XP_528129
863
96543
Y249
N
E
I
F
F
D
R
Y
P
D
S
I
L
E
H
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535063
929
104136
Y315
N
E
I
F
F
D
R
Y
P
D
S
I
L
E
H
Cat
Felis silvestris
Mouse
Mus musculus
P49717
862
96718
Y248
N
E
I
F
F
D
R
Y
P
D
S
I
L
E
H
Rat
Rattus norvegicus
NP_387500
862
96552
Y248
N
E
I
F
F
D
R
Y
P
D
S
I
L
E
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515513
863
97108
F249
N
E
V
F
F
D
R
F
P
D
S
I
L
E
H
Chicken
Gallus gallus
XP_424376
859
96866
Y245
N
E
I
F
F
D
R
Y
P
D
S
I
L
E
H
Frog
Xenopus laevis
P30664
863
97105
Y249
N
E
I
F
F
E
R
Y
P
D
S
I
L
E
H
Zebra Danio
Brachydanio rerio
NP_944595
750
84021
Y175
L
D
L
N
E
P
L
Y
M
Q
K
L
D
E
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
Y252
N
E
M
F
F
E
R
Y
P
A
A
L
L
E
H
Honey Bee
Apis mellifera
XP_624670
636
71159
T61
T
G
T
T
G
G
A
T
I
V
A
S
S
E
H
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
I184
H
T
I
P
D
V
S
I
K
P
G
L
E
G
F
Sea Urchin
Strong. purpuratus
XP_801985
910
101460
Y294
N
E
M
F
F
E
R
Y
P
D
T
N
L
E
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
S141
A
P
S
K
G
R
P
S
T
I
R
E
V
K
A
Baker's Yeast
Sacchar. cerevisiae
P30665
933
104985
I284
K
D
C
M
V
S
L
I
V
D
N
N
L
D
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
87.6
N.A.
94.9
95.1
N.A.
92.4
86.3
85.7
71.3
N.A.
60.1
42.1
28.1
63.3
Protein Similarity:
100
100
N.A.
90
N.A.
97
97.3
N.A.
96.1
93.1
92.9
78.7
N.A.
77.3
54.3
46.9
76.3
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
86.6
100
93.3
13.3
N.A.
66.6
13.3
6.6
73.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
100
33.3
N.A.
93.3
20
20
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.9
42.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.5
62.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
7
0
0
7
14
0
0
0
7
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
14
0
0
7
47
0
0
0
67
0
0
7
7
0
% D
% Glu:
0
67
0
0
7
20
0
0
0
0
0
7
7
80
0
% E
% Phe:
0
0
0
67
67
0
0
7
0
0
0
0
0
0
7
% F
% Gly:
0
7
0
0
14
7
0
0
0
0
7
0
0
7
0
% G
% His:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
74
% H
% Ile:
0
0
54
0
0
0
0
14
7
7
0
54
0
0
7
% I
% Lys:
7
0
0
7
0
0
0
0
7
0
7
0
0
7
0
% K
% Leu:
7
0
7
0
0
0
14
0
0
0
0
20
74
0
0
% L
% Met:
0
0
14
7
0
0
0
0
7
0
0
0
0
0
0
% M
% Asn:
67
0
0
7
0
0
0
0
0
0
7
14
0
0
0
% N
% Pro:
0
7
0
7
0
7
7
0
67
7
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
7
67
0
0
0
7
0
0
0
0
% R
% Ser:
0
0
7
0
0
7
7
7
0
0
54
7
7
0
0
% S
% Thr:
7
7
7
7
0
0
0
7
7
0
7
0
0
0
0
% T
% Val:
0
0
7
0
7
7
0
0
7
7
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
67
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _